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Finally, rodents develop neuropathy within weeks, whereas human DN unfolds over years, allowing compensatory mechanisms that animal models simply lack

Prior clinical studies questioned whether older RBCs are equally safe and effective as fresh RBCs, utilizing endpoints such as a multiple organ dysfunction score (MODS) [25], mortality [28] or other combinations of morbidity and mortality [29, 30]

The effect of insulinemia on fat metabolism and inflammation Insulin resistance/insulinemia, genetics, and metabolic syndrome account for most cases of MASLD [231, 235]

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